Article
Overexpression of connexin43 alters the mutant phenotype of midgestational wnt-1 null mice resulting in recovery of the midbrain and cerebellum.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology - 1 Mar 2005
Melloy Patricia G, Kusnierczyk Michelle K, Meyer Rita A, Lo Cecilia W, Desmond Mary E
Abstract excerpt
The midbrain-hindbrain (MHB) junction plays a key role in the patterning of the embryonic neural tube and the formation of brain structures such as the cerebellum. The mitogen wnt-1 is critical for cerebellar development, as evidenced by the lack of MHB region and cerebellar formation in the wnt-1 null embryo. We have generated wnt-1 null embryos overexpressing the gap junction gene connexin43 by crossing wnt-1...
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