Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin.

doi:10.1016/j.nbd.2008.04.012

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Article

Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin.

Neurobiology of disease - 1 Aug 2008

Powell K L, Kyi M, Reid C A, Paradiso L, D'Abaco G M, Kaye A H, Foote S J, O'Brien T J

Abstract excerpt

Stargazin is membrane bound protein involved in trafficking, synapse anchoring and biophysical modulation of AMPA receptors. A quantitative trait locus in chromosome 7 containing the stargazin gene has been identified as controlling the frequency and duration of absence seizures in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Furthermore, mutations in this gene result in the Stargazer mouse that...

Topics

Animals
Calcium Channels
Cerebral Cortex
Disease Models, Animal
Epilepsy, Absence
Genetic Predisposition to Disease
Mutation
Neural Pathways
RNA, Messenger
Rats
Rats, Mutant Strains
Somatosensory Cortex
Thalamus
Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 18556211
DOI: 10.1016/j.nbd.2008.04.012

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