Article
Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin.
Neurobiology of disease - 1 Aug 2008
Powell K L, Kyi M, Reid C A, Paradiso L, D'Abaco G M, Kaye A H, Foote S J, O'Brien T J
Abstract excerpt
Stargazin is membrane bound protein involved in trafficking, synapse anchoring and biophysical modulation of AMPA receptors. A quantitative trait locus in chromosome 7 containing the stargazin gene has been identified as controlling the frequency and duration of absence seizures in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Furthermore, mutations in this gene result in the Stargazer mouse that...
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