Article
NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis.
Journal of bacteriology - 1 May 1998
Miesel L, Weisbrod T R, Marcinkeviciene J A, Bittman R, Jacobs W R
Abstract excerpt
Isoniazid (INH) is a highly effective drug used in the treatment and prophylaxis of Mycobacterium tuberculosis infections. Resistance to INH in clinical isolates has been correlated with mutations in the inhA, katG, and ahpC genes. In this report, we describe a new mechanism for INH resistance in...
Topics
- Amino Acid Sequence
- Antitubercular Agents
- Bacterial Proteins
- Drug Resistance, Microbial
- Genetic Complementation Test
- Isoniazid
- Malate Dehydrogenase
- Microbial Sensitivity Tests
- Models, Biological
- Molecular Sequence Data
- Mutation
- Mycobacterium
- NAD
- NADH Dehydrogenase
- Oxidation-Reduction