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Article

NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis.

Journal of bacteriology - 1 May 1998

Miesel L, Weisbrod T R, Marcinkeviciene J A, Bittman R, Jacobs W R

Abstract excerpt

Isoniazid (INH) is a highly effective drug used in the treatment and prophylaxis of Mycobacterium tuberculosis infections. Resistance to INH in clinical isolates has been correlated with mutations in the inhA, katG, and ahpC genes. In this report, we describe a new mechanism for INH resistance in Mycobacterium smegmatis. Mutations that reduce NADH dehydrogenase activity (Ndh; type II) cause multiple phenotypes,...

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Identifiers

PMID: 9573199
DOI: 10.1128/JB.180.9.2459-2467.1998
PMCID: PMC107189

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