Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.

doi:10.1086/515362

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Article

Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.

The Journal of infectious diseases - 1 Sept 1998

Basso L A, Zheng R, Musser J M, Jacobs W R, Blanchard J S

Abstract excerpt

Mutants in the structural gene of the inhA-encoded NADH-dependent 2-trans enoyl-acyl carrier protein reductase were identified from isoniazid-resistant clinical isolates of Mycobacterium tuberculosis. Recombinant InhA proteins with defined single amino acid replacements were expressed in Escheric...

Topics

Antitubercular Agents
Bacterial Proteins
Drug Resistance, Microbial
Humans
Isoniazid
Mutagenesis
Mutation
Mycobacterium tuberculosis
NAD
Oxidoreductases
Tuberculosis

Source

Open in PubMed

Identifiers

PMID: 9728546
DOI: 10.1086/515362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9728546-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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