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Article

Two novel mutations in the sixth transmembrane segment of the thyrotropin receptor gene causing hyperfunctioning thyroid nodules.

Thyroid : official journal of the American Thyroid Association - 1 Apr 2005

Gozu Hulya, Avsar Melike, Bircan Rifat, Claus Maren, Sahin Serap, Sezgin Ozlem, Deyneli Oguzhan, Paschke Ralf, Cirakoglu Beyazit, Akalin Sema

Abstract excerpt

Autonomously functioning thyroid nodules (AFTNs) can present as hyperfunctioning adenomas or toxic multinodular goiters. In the last decade, a large number of activating mutations have been identified in the thyrotropin receptor (TSHR) gene in autonomously functioning thyroid nodules. Most have been situated close to, or within the sixth transmembrane segment and third intracellular loop of the TSHR where the...

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Source

Identifiers

PMID: 15876166
DOI: 10.1089/thy.2005.15.389

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two novel mutations in the sixth transmembrane segment of the thyrotropin receptor gene causing hyperfunctioning thyroid nodules.PMID 15876166Read ↗

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