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Article

Mutated E-cadherin: genomic and functional characterization in thyroid cells from the KAT family.

Thyroid : official journal of the American Thyroid Association - 1 Nov 2004

Rocha Ana Sofia, De Wever Olivier, Moreira Severina, Costa Maria José, Vandekerckhove Joel, Mareel Marc, Soares Paula

Abstract excerpt

Members of a family of thyroid cell lines (KAT) were analyzed because they expressed a higher molecular weight (135 kd) form of E-cadherin at their surface. We found that this aberrant E-cadherin is the result of a point mutation in the exon 9 donor splice site causing a skipping of exon 9 with consequent deletion of the corresponding aminoacids on E-cadherin protein. As a spin-off, we report that the various...

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Identifiers

PMID: 15671768
DOI: 10.1089/thy.2004.14.902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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