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A novel Gorilla-derived oncolytic Adenovirus with natural selective replication in cancer cells

2026-03-01

Abstract excerpt

Oncolytic virotherapy exploits viruses to selectively infect and destroy cancer cells while sparing normal tissues and represents a promising strategy in oncology. Human adenovirus type 5 (HAd5), although widely used, shows limited clinical efficacy due to high levels of preexisting immunity and suboptimal tumor selectivity. In this study, we evaluated novel gorilla-derived adenoviruses (GRAd) as alternative oncol...

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Literature Corpus work
47edea43-a784-53bf-88a8-9459b246840a
DOI
10.64898/2026.02.26.708271
Open publication

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