Article
Evaluation of E1A double mutant oncolytic adenovectors in anti-glioma gene therapy.
Journal of medical virology - 1 Sept 2008
Ulasov Ilya V, Tyler Matthew A, Rivera Angel A, Nettlebeck Dirk M, Douglas Joanne T, Lesniak Maciej S
Abstract excerpt
Malignant glioma, in particular glioblastoma multiforme (GBM), represents one of the most devastating cancers currently known and existing treatment regimens do little to change patient prognosis. Conditionally replicating adenoviral vectors (CRAds) represent attractive experimental anti-cancer agents with potential for clinical application. However, early protein products of the wild type adenovirus...
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