Article
Evaluation of E1-mutant adenoviruses as conditionally replicating agents for cancer therapy.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Nov 2000
Howe J A, Demers G W, Johnson D E, Neugebauer S E, Perry S T, Vaillancourt M T, Faha B
Abstract excerpt
The oncolytic effect of adenoviruses may provide an efficient means to destroy tumor tissue if viruses could be developed with sufficient selectivity and efficacy. In this report we have characterized several adenoviruses, each with different mutations in the E1 region, for selective cytopathic effect in tumor cells in vitro and for their ability to inhibit tumor growth in vivo. Of the E1 mutants tested, we have...
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