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Article

Replication-selective oncolytic adenoviruses: virotherapy aimed at genetic targets in cancer.

Oncogene - 27 Dec 2000

Kirn D

Abstract excerpt

Replication-selective oncolytic adenoviruses represent a novel cancer treatment platform. Clinical studies have demonstrated the safety and feasibility of the approach, including the delivery of adenovirus to tumors through the bloodstream (Heise et al., 1999b; Reid et al., 1999; Nemunaitis et al., 1999). The inherent ability of replication-competent adenoviruses to sensitize tumor cells to chemotherapy was a...

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PMID: 11426652
DOI: 10.1038/sj.onc.1204094

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