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Spectrum-Wide Exploration of Human Adenoviruses for Breast Cancer Therapy

29 May 2020

Abstract excerpt

Oncolytic adenoviruses (Ads) are promising tools for cancer therapeutics. However, most Ad-based therapies utilize Ad type 5 (Ad5), which displays unsatisfying efficiency in clinical trials, partly due to the low expression levels of its primary coxsackievirus and adenovirus receptor (CAR) on tumor cells. Since the efficacy of virotherapy strongly relies on efficient transduction of targeted tumor cells, initial...

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PMID: 32486014
DOI: 10.3390/cancers12061403

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