Article
Oncolytic adenoviruses: design, generation, and experimental procedures.
Current protocols in human genetics - 1 Jul 2013
Davydova Julia, Yamamoto Masato
Abstract excerpt
Oncolytic adenoviruses are designed to take advantage of the virus' native ability to replicate in cancer cells to induce oncolysis. Subsequently, the released viral progeny spread and kill the neighboring cancer cells. These characteristics, together with the ability of adenovirus to infect a broad spectrum of cells, its well understood replication machinery, and relative ease of manufacture have led to the...
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