Article
T47DCO cells, genetically unstable and containing estrogen receptor mutations, are a model for the progression of breast cancers to hormone resistance.
Cancer research - 1 Oct 1990
Graham M L, Krett N L, Miller L A, Leslie K K, Gordon D F, Wood W M, Wei L L, Horwitz K B
Abstract excerpt
We postulate that one mechanism for the progression of breast cancers to hormone resistance involves the acquisition of mutant estrogen receptors (ER)4 by genetically unstable cell subpopulations. The T47D human breast cancer cell line may be a model for such progression, having sublines that are...
Topics
- Amino Acid Sequence
- Base Sequence
- Breast Neoplasms
- DNA, Neoplasm
- Drug Resistance
- Estradiol
- Gene Library
- Humans
- Molecular Sequence Data
- Mutation
- Phenotype
- Polyploidy
- Receptors, Estrogen
- Receptors, Progesterone
- Tamoxifen