Article
The natural L370F ERα variant confers endocrine resistance and sensitivity to ATRA in metastatic breast cancer cells.
Cell communication and signaling : CCS - 5 Jan 2026
Cipolletti Manuela, Bellucci Claudia, Fiocchetti Marco, Pavlin Matic, Magistrato Alessandra, Acconcia Filippo
Abstract excerpt
BACKGROUND: Metastatic breast cancer (MBC) remains a major clinical challenge, particularly in estrogen receptor α (ERα)-positive patients who develop resistance to endocrine therapy (ET). While hotspot mutations such as Y537S in the ligand-binding domain (LBD) are well-characterized drivers of resistance, other ERα variants remain poorly studied. Understanding the molecular mechanisms underlying resistance in...
Topics
- Humans
- Cell Line
- Estrogen Receptor alpha
- Mutation
- Breast Neoplasms
- Tretinoin
- Neoplasm Metastasis
- Drug Resistance, Neoplasm
- Endocrine System
- Transcription, Genetic
- Gene Expression Regulation, Neoplastic
- Gene Expression Profiling
- Ligands