Article

Modulation of ATP8B1 Gene expression in Colorectal Cancer Cells Suggest its Role as a Tumor Suppressor

2020-11-16

Abstract excerpt

Sporadic colorectal cancer (CRC) develops through distinct molecular events. Loss of 18q chromosome is a conspicuous event in the progression of adenoma to carcinoma. There is limited information regarding the molecular effectors of this event. Earlier, we had reported ATP8B1 as a novel gene associated with CRC. ATP8B1 belongs to the family of P-type ATPases (P4 ATPase) that primarily function to facilitate the tr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52561108-29fb-5118-bcda-2ba904e50618
DOI: 10.20944/preprints202011.0437.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modulation of ATP8B1 Gene expression in Colorectal Cancer Cells Suggest its Role as a Tumor SuppressorDOI 10.20944/preprints202011.0437.v1Read

The Role of ATP-Binding Cassette Subfamily A in Colorectal Cancer Progression and ResistanceSemantic proximity Read

Identification of ABCA5 among ATP-Binding Cassette Transporter Family as a New Biomarker for Colorectal CancerSemantic proximity Read

APOC2 accelerates colorectal cancer progression via modulating lipid metabolism and transcriptional activity of PHF8Semantic proximity Read

Claudin‐1, a Biomarker of Epithelial‐Mesenchymal Transformation, Enhances Lipid Metabolism in Colorectal Cancer Cells to Promote Tumor MetastasisSemantic proximity Read

The Phospholipid Flippase ATP8B1 is Involved in the Pathogenesis of Ulcerative Colitis via Establishment of Intestinal Barrier FunctionSemantic proximity Read

Studying the function of the alternative spliced isoform Rac1b in colorectal cancerSemantic proximity Read

ABCE1 facilitates tumour progression via aerobic glycolysis and inhibits cell death in human colorectal cancer cells through the p53 signalling pathwaySemantic proximity Read

Wild-type IDH1 Knockout Leads to G0/G1 Arrest, Impairs Cancer Cell Proliferation, Altering Glycolysis, and the TCA Cycle in Colon Cancer.Semantic proximity Read

Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapySemantic proximity Read

Identification of potential functional variants and genes at 18q21.1 associated with the carcinogenesis of colorectal cancer.Semantic proximity Read

ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin-1-dependent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone.Semantic proximity Read

Decreased mitochondrial transcription factor A and mitochondrial DNA copy number promote cyclin-dependent kinase inhibitor 1A expression and reduce tumorigenic properties of colorectal cancer cellsSemantic proximity Read