Article
A potassium‐chloride co‐transporter with altered genome architecture functions as a suppressor in glioma
29 Apr 2024
Abstract excerpt
Abstract Gliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi‐C data, we identified a potassium‐chloride co‐transporter SLC12A5 associated with disrupted topologically...
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