Article
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.
Cancer research - 1 Jan 2005
Bavoux Clarisse, Leopoldino Andréia Machado, Bergoglio Valérie, O-Wang Jiyang, Ogi Tomoo, Bieth Anne, Judde Jean-Gabriel, Pena Sérgio Danilo Junho, Poupon Marie-France, Helleday Thomas, Tagawa Masatoshi, Machado Carlosrenato, Hoffmann Jean-Sébastien, Cazaux Christophe
Abstract excerpt
It is currently widely accepted that genetic instability is key to cancer development. Many types of cancers arise as a consequence of a gradual accumulation of nucleotide aberrations, each mutation conferring growth and/or survival advantage. Genetic instability could also proceed in sudden bursts leading to a more drastic upheaval of structure and organization of the genome. Genetic instability, as an operative...
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