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<i>DNA polymerase</i> θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

12 Jul 2010

Abstract excerpt

"Replicative stress" is one of the main factors underlying neoplasia from its early stages. Genes involved in DNA synthesis may therefore represent an underexplored source of potential prognostic markers for cancer. To this aim, we generated gene expression profiles from two independent cohorts (France, n=206; United Kingdom, n=117) of patients with previously untreated primary breast cancers. We report here that...

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PMID: 20624954
DOI: 10.1073/pnas.0910759107

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