Article

Up-Regulation of the Error-Prone DNA Polymerase κ Promotes Pleiotropic Genetic Alterations and Tumorigenesis

2005-01-01

Abstract excerpt

Abstract It is currently widely accepted that genetic instability is key to cancer development. Many types of cancers arise as a consequence of a gradual accumulation of nucleotide aberrations, each mutation conferring growth and/or survival advantage. Genetic instability could also proceed in sudden bursts leading to a more drastic upheaval of structure and organization of the genome. Genetic instability, as an o...

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Identifiers and source

Literature Corpus work: 25191d37-6078-5102-ba95-679b33717022
DOI: 10.1158/0008-5472.325.65.1

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