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Article

Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin

28 May 2014

Abstract excerpt

In nonmammalian vertebrates, the functional units of hemostasis are thrombocytes. Thrombocytes are thought to arise from bipotent thrombocytic/erythroid progenitors (TEPs). TEPs have been experimentally demonstrated in avian models of hematopoiesis, and mammals possess functional equivalents known as megakaryocyte/erythroid progenitors (MEPs). However, the presence of TEPs in teleosts has only been speculated. To...

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PMID: 24869937
DOI: 10.1182/blood-2014-03-564682

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