Article
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities.
Molecular and cellular biology - 1 Jan 2005
Lambourne Sarah L, Sellers Lynda A, Bush Toby G, Choudhury Shewly K, Emson Piers C, Suh Yoo-Hun, Wilkinson Lawrence S
Abstract excerpt
Abnormal tau phosphorylation occurs in several neurodegenerative disorders, including Alzheimer's disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). Here, we compare mechanisms of tau phosphorylation in mouse models of FTDP-17 and AD. Mice expressing a mutated form of human tau associated with FTDP-17 (tau(V337M)) showed age-related increases in exogenous tau...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.