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Article

Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy

29 Jun 2010

Abstract excerpt

AIM: Tau protein is a prominent component of paired helical filaments in Alzheimer's disease (AD) and other tauopathies. While the abnormal phosphorylation of tau on serine and threonine has been well established in the disease process, its phosphorylation on tyrosine has only recently been described. We previously showed that the Src family non-receptor tyrosine kinases (SFKs) Fyn and Src phosphorylate tau on...

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PMID: 20609109
DOI: 10.1111/j.1365-2990.2010.01103.x

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