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Article

Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e.

Neuron - 20 Jan 2005

Lou Hong, Kim Soo-Kyung, Zaitsev Eugene, Snell Chris R, Lu Bai, Loh Y Peng

Abstract excerpt

Activity-dependent secretion of BDNF is important in mediating synaptic plasticity, but how it is achieved is unclear. Here we uncover a sorting motif receptor-mediated mechanism for regulated secretion of BDNF. X-ray crystal structure analysis revealed a putative sorting motif, I(16)E(18)I(105)D(106), in BDNF, which when mutated at the acidic residues resulted in missorting of proBDNF to the constitutive pathway...

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Source

Identifiers

PMID: 15664176
DOI: 10.1016/j.neuron.2004.12.037

Genes

BDNF
CPE
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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