Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A complex web of signal-dependent trafficking underlies the triorganellar distribution of P-selectin in neuroendocrine PC12 cells.

The Journal of cell biology - 28 Jun 1999

Blagoveshchenskaya A D, Hewitt E W, Cutler D F

Abstract excerpt

By analyzing the trafficking of HRP-P-selectin chimeras in which the lumenal domain of P-selectin was replaced with horseradish peroxidase, we determined the sequences needed for targeting to synaptic-like microvesicles (SLMV), dense core granules (DCG), and lysosomes in neuroendocrine PC12 cells. Within the cytoplasmic domain of P-selectin, Tyr777 is needed for the appearance of P-selectin in immature and mature...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brefeldin A
Share to Cell Fractionation
Share to Cytoplasmic Granules

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Organelles

Share to P-Selectin

Share to PC12 Cells

Share to Synaptic Vesicles

Share to Synaptophysin

Source

Open in PubMed Open full text

Identifiers

PMID: 10385522
DOI: 10.1083/jcb.145.7.1419
PMCID: PMC2133164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A complex web of signal-dependent trafficking underlies the triorganellar distribution of P-selectin in neuroendocrine PC12 cells.PMID 10385522Read ↗

Sorting to synaptic-like microvesicles from early and late endosomes requires overlapping but not identical targeting signals.Semantic proximity Read ↗

P-selectin targeting to secretory lysosomes of Rbl-2H3 cells.Semantic proximity Read ↗

Expression of ARF6 mutants in neuroendocrine cells suggests a role for ARF6 in synaptic vesicle biogenesis.Semantic proximity Read ↗

A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization.Semantic proximity Read ↗

Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail.Semantic proximity Read ↗

AP-3 adaptor functions in targeting P-selectin to secretory granules in endothelial cells.Semantic proximity Read ↗

Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain.Semantic proximity Read ↗

YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals.Semantic proximity Read ↗

P‐Selectin and CD63 Use Different Mechanisms for Delivery to Weibel–Palade BodiesSemantic proximity Read ↗

Subcellular localization and trafficking of polycystinsSemantic proximity Read ↗

Rab4 regulates formation of synaptic-like microvesicles from early endosomes in PC12 cells.Semantic proximity Read ↗

Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.