Article
Amino acid residues of G-protein-coupled receptors critical for endoplasmic reticulum export and trafficking.
Methods in enzymology - 1 Jan 2013
Nakamura Motonao, Yasuda Daisuke, Hirota Nobuaki, Yamamoto Teruyasu, Yamaguchi Satoshi, Shimizu Takao, Nagamune Teruyuki
Abstract excerpt
Analysis of the structural features of rhodopsin-type G-protein-coupled receptors (GPCRs) revealed the existence of an additional α-helix, termed helix 8, in the C-terminal tail. Furthermore, these GPCRs were determined to possess several conserved residues in their transmembrane domains. The functional deficiencies of receptors in which these domains or residues have been mutated have not been examined in living...
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