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Genome sequence and attenuating mutations in West Nile virus isolate from Mexico.

Emerging infectious diseases - 1 Dec 2004

Beasley David W C, Davis C Todd, Estrada-Franco Jose, Navarro-Lopez Roberto, Campomanes-Cortes Arturo, Tesh Robert B, Weaver Scott C, Barrett Alan D T

Abstract excerpt

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.

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Identifiers

PMID: 15663867
DOI: 10.3201/eid1012.040647
PMCID: PMC3323401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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