Article
Internally deleted WNV genomes isolated from exotic birds in New Mexico: function in cells, mosquitoes, and mice.
Virology - 25 May 2012
Pesko Kendra N, Fitzpatrick Kelly A, Ryan Elizabeth M, Shi Pei-Yong, Zhang Bo, Lennon Niall J, Newman Ruchi M, Henn Matthew R, Ebel Gregory D
Abstract excerpt
Most RNA viruses exist in their hosts as a heterogeneous population of related variants. Due to error prone replication, mutants are constantly generated which may differ in individual fitness from the population as a whole. Here we characterize three WNV isolates that contain, along with full-length genomes, mutants with large internal deletions to structural and nonstructural protein-coding regions. The...
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