Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

West Nile 25A virus infection of B-cell-deficient ((micro)MT) mice: characterization of neuroinvasiveness and pseudoreversion of the viral envelope protein.

The Journal of general virology - 1 Mar 2008

Chambers Thomas J, Droll Deborah A, Walton Andrew H, Schwartz Julie, Wold William S M, Nickells Janice

Abstract excerpt

The attenuated West Nile virus 25A strain (WN25A) was investigated for its neuroinvasive properties in B-cell-deficient (microMT) mice. After peripheral inoculation, WN25A caused fatal encephalitis in the majority of 6-8-week-old mice, characterized by a systemic infection with viraemia, moderate virus burdens in peripheral tissues and a high titre of brain-associated virus. Mice generally succumbed to infection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Encephalitis, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation

Share to Vero Cells

Share to Viral Envelope Proteins

Share to Viremia

Share to West Nile Fever

Share to West Nile virus

Source

Identifiers

PMID: 18272752
DOI: 10.1099/vir.0.83297-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

West Nile 25A virus infection of B-cell-deficient ((micro)MT) mice: characterization of neuroinvasiveness and pseudoreversion of the viral envelope protein.PMID 18272752Read ↗

Molecular determinants of virulence of West Nile virus in North America.Semantic proximity Read ↗

West Nile virus envelope proteins: nucleotide sequence analysis of strains differing in mouse neuroinvasiveness.Semantic proximity Read ↗

In Vitro and in Vivo Evaluation of Mutations in the NS Region of Lineage 2 West Nile Virus Associated with Neuroinvasiveness in a Mammalian Model.Semantic proximity Read ↗

Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype.Semantic proximity Read ↗

Lethality of West Nile virus strains in a mouse modelSemantic proximity Read ↗

Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains.Semantic proximity Read ↗

An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse ModelSemantic proximity Read ↗

Characterization of the Mouse Neuroinvasiveness of Selected European Strains of West Nile VirusSemantic proximity Read ↗

Generation and Characterization of a Mouse-Adapted Makona Variant of Ebola Virus.Semantic proximity Read ↗

Loss of active neuroinvasiveness in attenuated strains of West Nile virus: pathogenicity in immunocompetent and SCID mice.Semantic proximity Read ↗

In vitro and in vivo characterization of a novel West Nile virus lineage 2 strainSemantic proximity Read ↗

Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral EvasionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.