Article
Envelope and pre-membrane protein structural amino acid mutations mediate diminished avian growth and virulence of a Mexican West Nile virus isolate.
The Journal of general virology - 1 Dec 2011
Langevin Stanley A, Bowen Richard A, Ramey Wanichaya N, Sanders Todd A, Maharaj Payal D, Fang Ying, Cornelius Jennine, Barker Christopher M, Reisen William K, Beasley David W C, Barrett Alan D T, Kinney Richard M, Huang Claire Y-H, Brault Aaron C
Abstract excerpt
The hallmark attribute of North American West Nile virus (WNV) strains has been high pathogenicity in certain bird species. Surprisingly, this avian virulent WNV phenotype has not been observed during its geographical expansion into the Caribbean, Central America and South America. One WNV variant (TM171-03-pp1) isolated in Mexico has demonstrated an attenuated phenotype in two widely distributed North American...
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