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Article

Genotyping and functional analysis of the D104N variant of human endostatin.

Cancer biology & therapy - 1 Dec 2004

Macpherson Gordon R, Singh Arun S, Bennett Charles L, Venzon David J, Liewehr David J, Franks Michael E, Dahut William L, Kantoff Philip W, Price Douglas K, Figg William D

Abstract excerpt

Endostatin is an endogenous inhibitor of angiogenesis derived from the extracellular matrix protein collagen XVIII. It has been reported that a variation at the 104 position (D104N) of human endostatin is associated with an increased risk of prostate cancer, potentially indicating that this protein variant is less active as an anti-angiogenic agent. Herein we reported the results of genotyping 389 patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15662127
DOI: 10.4161/cbt.3.12.1453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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