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Article

Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors.

Clinics (Sao Paulo, Brazil) - 1 Jan 2012

Mariani Beatriz Marinho de Paula, Trarbach Ericka Barbosa, Ribeiro Tamaya Castro, Pereira Maria Adelaide Albergaria, Mendonca Berenice Bilharinho, Fragoso Maria Candida Barisson Villares

Abstract excerpt

OBJECTIVE: Endostatin is a potent endogenous inhibitor of angiogenesis. It is derived from the proteolytic cleavage of collagen XVIII, which is encoded by the COL18A1 gene. A polymorphic COL18A1 allele encoding the functional polymorphism p.D104N impairs the activity of endostatin, resulting in a decreased ability to inhibit angiogenesis. This polymorphism has been previously analyzed in many types of cancer and...

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Identifiers

PMID: 22358232
DOI: 10.6061/clinics/2012(02)02
PMCID: PMC3275125

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