Article
Autoantibodies to endostatin in patients with breast cancer: correlation to endostatin levels and clinical outcome.
British journal of cancer - 10 Apr 2006
Bachelot T, Ratel D, Menetrier-Caux C, Wion D, Blay J-Y, Berger F
Abstract excerpt
Circulating autoantibodies to self-antigens overexpressed by cancer cells are common in cancer patients. As specific proteins are expressed during neoangiogenesis, a similar phenomenon might occur with particular antigens of tumour vessels. Collagen XVIII, from which endostatin is cleaved, is highly expressed in the perivascular basement membrane of tumour-associated blood vessels and autoantibodies to endostatin...
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