Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma.

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Article

Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma.

Cancer research - 1 Jan 1999

Dhanabal M, Ramchandran R, Volk R, Stillman I E, Lombardo M, Iruela-Arispe M L, Simons M, Sukhatme V P

Abstract excerpt

Endostatin is a Mr 20,000 COOH-terminal fragment of collagen XVIII that inhibits the growth of several primary tumors. We report here the cloning and expression of mouse endostatin in both prokaryotic and eukaryotic expression systems. Soluble recombinant protein expressed in yeast (15-20 mg/L) i...

Topics

Animals
Antineoplastic Agents
Carcinoma, Renal Cell
Cattle
Collagen
Collagen Type XVIII
Endostatins
Kidney Neoplasms
Mice
Mutation
Neoplasms, Experimental
Peptide Fragments
Rabbits
Recombinant Proteins
Saccharomyces cerevisiae
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9892206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9892206-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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