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Article

Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma.

Cancer research - 1 Jan 1999

Dhanabal M, Ramchandran R, Volk R, Stillman I E, Lombardo M, Iruela-Arispe M L, Simons M, Sukhatme V P

Abstract excerpt

Endostatin is a Mr 20,000 COOH-terminal fragment of collagen XVIII that inhibits the growth of several primary tumors. We report here the cloning and expression of mouse endostatin in both prokaryotic and eukaryotic expression systems. Soluble recombinant protein expressed in yeast (15-20 mg/L) inhibited the proliferation and migration of endothelial cells in response to stimulation by basic fibroblast growth...

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PMID: 9892206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma.PMID 9892206Read ↗

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Characterization of overexpressed mutant proteins in mammalian cells.Semantic proximity Read ↗

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor.Semantic proximity Read ↗

Serum endostatin levels are elevated and correlate with serum vascular endothelial growth factor levels in patients with stage IV clear cell renal cancer.Semantic proximity Read ↗

Linking antibody Fc domain to endostatin significantly improves endostatin half-life and efficacy.Semantic proximity Read ↗

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Genotyping and functional analysis of the D104N variant of human endostatin.Semantic proximity Read ↗

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Isolation and characterization of the circulating form of human endostatinSemantic proximity Read ↗

Monitoring of the tissue distribution of fibroblast growth factor containing a high mannose-type sugar chain produced in mutant yeast.Semantic proximity Read ↗

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