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Article

Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure.

Circulation research - 18 Feb 2005

Kostetskii Igor, Li Jifen, Xiong Yanming, Zhou Rong, Ferrari Victor A, Patel Vickas V, Molkentin Jeffery D, Radice Glenn L

Abstract excerpt

The structural integrity of the heart is maintained by the end-to-end connection between the myocytes called the intercalated disc. The intercalated disc contains different junctional complexes that enable the myocardium to function as a syncytium. One of the junctional complexes, the zonula adherens or adherens junction, consists of the cell adhesion molecule, N-cadherin, which mediates strong homophilic...

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Identifiers

PMID: 15662031
DOI: 10.1161/01.RES.0000156274.72390.2c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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