N-Cadherin promotes cardiac regeneration by potentiating pro-mitotic β-Catenin signaling in cardiomyocytes

Abstract excerpt

Adult human hearts exhibit limited regenerative capacity. Post-injury cardiomyocyte (CM) loss can lead to myocardial dysfunction and failure. Although neonatal mammalian hearts can regenerate, the underlying molecular mechanisms remain elusive. Herein, comparative transcriptome analyses identify adherens junction protein N-Cadherin as a crucial regulator of CM proliferation/renewal. Its expression correlates...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Structural Anomalies and Repair
• Share to Congenital heart defects research
• Share to Tissue Engineering and Regenerative Medicine