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Article

N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility.

Journal of molecular and cellular cardiology - 1 Mar 2008

Li Jifen, Levin Mark D, Xiong Yanming, Petrenko Nataliya, Patel Vickas V, Radice Glenn L

Abstract excerpt

Cardiac-specific deletion of the murine gene (Cdh2) encoding the cell adhesion molecule, N-cadherin, results in disassembly of the intercalated disc (ICD) structure and sudden arrhythmic death. Connexin 43 (Cx43)-containing gap junctions are significantly reduced in the heart after depleting N-ca...

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Identifiers

PMID: 18201716
DOI: 10.1016/j.yjmcc.2007.11.013
PMCID: PMC2314673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18201716-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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