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Article

Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia.

Journal of cell science - 15 Feb 2012

Li Jifen, Goossens Steven, van Hengel Jolanda, Gao Erhe, Cheng Lan, Tyberghein Koen, Shang Xiying, De Rycke Riet, van Roy Frans, Radice Glenn L

Abstract excerpt

It is generally accepted that the intercalated disc (ICD) required for mechano-electrical coupling in the heart consists of three distinct junctional complexes: adherens junctions, desmosomes and gap junctions. However, recent morphological and molecular data indicate a mixing of adherens junctional and desmosomal components, resulting in a 'hybrid adhering junction' or 'area composita'. The α-catenin family...

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Source

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Identifiers

PMID: 22421363
DOI: 10.1242/jcs.098640
PMCID: PMC3311935

Genes

PKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia.PMID 22421363Read ↗

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