Article
Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.
The Journal of biological chemistry - 6 May 2005
Higginbottom Adrian, Cain Stuart A, Woodruff Trent M, Proctor Lavinia M, Madala Praveen K, Tyndall Joel D A, Taylor Stephen M, Fairlie David P, Monk Peter N
Abstract excerpt
The C terminus is responsible for all of the agonist activity of C5a at human C5a receptors (C5aRs). In this report we have mapped the ligand binding site on the C5aR using a series of agonist and antagonist peptide mimics of the C terminus of C5a as well as receptors mutated at putative interaction sites (Ile(116), Arg(175,) Arg(206), Glu(199), Asp(282), and Val(286)). Agonist peptide 1...
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