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Article

Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor.

Biochemical pharmacology - 15 Jun 2001

Cain S A, Woodruff T M, Taylor S M, Fairlie D P, Sanderson S D, Monk P N

Abstract excerpt

The cyclic C5a receptor antagonist, phenylalanine [L-ornithine-proline-D-cyclohexylalanine-tryptophan-arginine] (F-[OPchaWR]), has approximately 1000-fold less affinity for the C5a receptor (C5aR) on murine polymorphonuclear leukocytes than on human. Analysis of C5aR from different species shows that a possible cause of this difference is the variation in the sequence of the first extracellular loop of the...

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PMID: 11377387
DOI: 10.1016/s0006-2952(01)00608-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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