Article
Arginine 206 of the C5a receptor is critical for ligand recognition and receptor activation by C-terminal hexapeptide analogs.
The Journal of biological chemistry - 7 Jul 1995
DeMartino J A, Konteatis Z D, Siciliano S J, Van Riper G, Underwood D J, Fischer P A, Springer M S
Abstract excerpt
C5a is a 74-amino-acid glycoprotein whose receptor is a member of the rhodopsin superfamily. While antagonists have been generated to many of these receptors, similar efforts directed at family members whose natural ligands are proteins have met with little success. The recent development of hexa...
Topics
- Amino Acid Sequence
- Antigens, CD
- Arginine
- Binding Sites
- Complement C5a
- Dose-Response Relationship, Drug
- Humans
- Ligands
- Models, Biological
- Molecular Sequence Data
- Mutation
- Oligopeptides
- Receptor, Anaphylatoxin C5a
- Receptors, Complement
- Signal Transduction
- Structure-Activity Relationship