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Article

Arginine 206 of the C5a receptor is critical for ligand recognition and receptor activation by C-terminal hexapeptide analogs.

The Journal of biological chemistry - 7 Jul 1995

DeMartino J A, Konteatis Z D, Siciliano S J, Van Riper G, Underwood D J, Fischer P A, Springer M S

Abstract excerpt

C5a is a 74-amino-acid glycoprotein whose receptor is a member of the rhodopsin superfamily. While antagonists have been generated to many of these receptors, similar efforts directed at family members whose natural ligands are proteins have met with little success. The recent development of hexapeptide analogs of C5a has allowed us to begin elucidation of the molecular events that lead to activation by combining...

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Identifiers

PMID: 7608153
DOI: 10.1074/jbc.270.27.15966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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