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Article

Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function.

The Journal of biological chemistry - 10 Nov 2000

Geva A, Lassere T B, Lichtarge O, Pollitt S K, Baranski T J

Abstract excerpt

Many hormones and sensory stimuli signal through a superfamily of seven transmembrane-spanning receptors to activate heterotrimeric G proteins. How the seven transmembrane segments of the receptors (a molecular architecture of bundled alpha-helices conserved from yeast to man) work as "on/off" switches remains unknown. Previously, we used random saturation mutagenesis coupled with a genetic selection in yeast to...

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Identifiers

PMID: 10952985
DOI: 10.1074/jbc.M005602200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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