Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C5a receptor activation. Genetic identification of critical residues in four transmembrane helices.

The Journal of biological chemistry - 28 May 1999

Baranski T J, Herzmark P, Lichtarge O, Gerber B O, Trueheart J, Meng E C, Iiri T, Sheikh S P, Bourne H R

Abstract excerpt

Hormones and sensory stimuli activate serpentine receptors, transmembrane switches that relay signals to heterotrimeric guanine nucleotide-binding proteins (G proteins). To understand the switch mechanism, we subjected 93 amino acids in transmembrane helices III, V, VI, and VII of the human chemoattractant C5a receptor to random saturation mutagenesis. A yeast selection identified 121 functioning mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Antigens, CD

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Gene Library

Share to Protein Structure, Secondary

Share to Receptors, Complement

Share to Sequence Deletion

Share to Yeasts

Source

Identifiers

PMID: 10336477
DOI: 10.1074/jbc.274.22.15757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C5a receptor activation. Genetic identification of critical residues in four transmembrane helices.PMID 10336477Read ↗

Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function.Semantic proximity Read ↗

Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop.Semantic proximity Read ↗

Arginine 206 of the C5a receptor is critical for ligand recognition and receptor activation by C-terminal hexapeptide analogs.Semantic proximity Read ↗

Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking.Semantic proximity Read ↗

Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor.Semantic proximity Read ↗

Evolutionary History of Calcium-Sensing Receptors Unveils Hyper/Hypocalcemia-Causing MutationsSemantic proximity Read ↗

Evolutionary history of calcium-sensing receptors unveils hyper/hypocalcemia-causing mutations.Semantic proximity Read ↗

A surface-exposed region of G(salpha) in which substitutions decrease receptor-mediated activation and increase receptor affinity.Semantic proximity Read ↗

Mutagenic mapping of helical structures in the transmembrane segments of the yeast alpha-factor receptor.Semantic proximity Read ↗

Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptorsSemantic proximity Read ↗

Dominant-negative mutations in the G-protein-coupled alpha-factor receptor map to the extracellular ends of the transmembrane segments.Semantic proximity Read ↗

Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.