IL-13 gene polymorphisms and their association with atopic asthma and rhinitis in Pakistani patients.

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Article

IL-13 gene polymorphisms and their association with atopic asthma and rhinitis in Pakistani patients.

Iranian journal of allergy, asthma, and immunology - 28 Aug 2013

Shazia Micheal, Kanza Minhas, Mehwish Ishaque, Irum Shabbir, Farida Ahmed, Asifa Ahmed

Abstract excerpt

Interleukin-13 (IL-13) is known to be a key regulator in immunoglobulin E (IgE) synthesis, mucus hypersecretion and airway hyperresponsiveness. Single nucleotide polymorphisms in IL-13 are associated with allergic phenotypes in several ethnically diverse populations.This study was performed in 214 atopic patients (asthma n=108, allergic rhinitis n=106) and sex-matched healthy controls (n=120). Genotyping of IL-13...

Topics

Asthma
Female
Genotype
Humans
Interleukin-13
Male
Polymorphism, Single Nucleotide
Rhinitis, Allergic
Rhinitis, Allergic, Perennial

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Open in PubMed

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PMID: 23996716

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