CNK, a RAF-binding multidomain protein required for RAS signaling.

doi:10.1016/s0092-8674(00)81766-3

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Article

CNK, a RAF-binding multidomain protein required for RAS signaling.

Cell - 30 Oct 1998

Therrien M, Wong A M, Rubin G M

Abstract excerpt

Kinase suppressor of ras (ksr) is required for efficient signal transmission within the RAS/MAPK cascade. A screen for mutations that modify a ksr-dependent phenotype identified a novel gene, connector enhancer of ksr (cnk), that functions upstream or in parallel to RAF in the RAS pathway. cnk en...

Topics

Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Animals
Carrier Proteins
Cell Differentiation
Cell Line
Cell Survival
Drosophila Proteins
Drosophila melanogaster
Evolution, Molecular
Eye
Genes, Dominant
Genes, Suppressor
Humans
Insect Proteins
Intercellular Junctions
Molecular Sequence Data
Mutagenesis

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