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Article

CNK, a RAF-binding multidomain protein required for RAS signaling.

Cell - 30 Oct 1998

Therrien M, Wong A M, Rubin G M

Abstract excerpt

Kinase suppressor of ras (ksr) is required for efficient signal transmission within the RAS/MAPK cascade. A screen for mutations that modify a ksr-dependent phenotype identified a novel gene, connector enhancer of ksr (cnk), that functions upstream or in parallel to RAF in the RAS pathway. cnk encodes a protein containing several protein-protein interaction domains, suggesting that it brings different signaling...

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PMID: 9814705
DOI: 10.1016/s0092-8674(00)81766-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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CNK, a RAF-binding multidomain protein required for RAS signaling.PMID 9814705Read ↗

Functional analysis of CNK in RAS signaling.Semantic proximity Read ↗

Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf 1Semantic proximity Read ↗

Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.Semantic proximity Read ↗

A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila.Semantic proximity Read ↗

Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism.Semantic proximity Read ↗

Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.Semantic proximity Read ↗

Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling.Semantic proximity Read ↗

An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and TumorsSemantic proximity Read ↗

Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate.Semantic proximity Read ↗

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