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Article

Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model.

Oncogene - 3 Apr 2003

Settle Mark, Gordon Michael D, Nadella Mythili, Dankort David, Muller William, Jacobs J Roger

Abstract excerpt

The ErbB-2/Neu receptor tyrosine kinase plays a causal role in tumorigenesis in mammals. Neu's carboxyl terminus contains five phosphorylated tyrosines that mediate transformation through interaction with cytoplasmic SH2 or PTB containing adaptor proteins. We show that Drosophila adaptors signal...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Tyrosine Phosphatases, Non-Receptor

Share to Proto-Oncogene Proteins c-raf

Share to Receptor, ErbB-2

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Source

Identifiers

PMID: 12673197
DOI: 10.1038/sj.onc.1206240

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12673197-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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