Article
Functional analysis of CNK in RAS signaling.
Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 1999
Therrien M, Wong A M, Kwan E, Rubin G M
Abstract excerpt
Connector enhancer of KSR (CNK) is a multidomain protein required for RAS signaling. Its C-terminal portion (CNK(C-term)) directly binds to RAF. Herein, we show that the N-terminal portion of CNK (CNK(N-term)) strongly cooperates with RAS, whereas CNK(C-term) efficiently blocks RAS- and RAF-dependent signaling when overexpressed in the Drosophila eye. Two effector loop mutants of RAS(V12), S35 and C40, which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.