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Article

The universal trend of amino acid gain-loss is caused by CpG hypermutability.

Journal of molecular evolution - 1 Oct 2008

Misawa Kazuharu, Kamatani Naoyuki, Kikuno Reiko F

Abstract excerpt

Understanding the cause of the changes in the amino acid composition of proteins is essential for understanding the evolution of protein functions. Since the early 1970s, it has been known that the frequency of some amino acids in protein sequences is increasing and that of others is decreasing. Recently, it was found that the trends of amino acid changes were similar in 15 taxa representing Bacteria, Archaea,...

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Identifiers

PMID: 18810523
DOI: 10.1007/s00239-008-9141-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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