Article
Detailed histopathologic characterization of the retinopathy, globe enlarged (rge) chick phenotype.
Molecular vision - 13 Jan 2005
Montiani-Ferreira Fabiano, Fischer Andy, Cernuda-Cernuda Rafael, Kiupel Matti, DeGrip Willem Johan, Sherry David, Cho Sa Sun, Shaw Gillian C, Evans Mark G, Hocking Paul M, Petersen-Jones Simon M
Abstract excerpt
PURPOSE: The purpose of this study was to characterize the morphological abnormalities in the retinas of chicks (Gallus gallus) suffering from the autosomal recessive disease, retinopathy, globe enlarged (rge/rge). METHODS: rge/rge affected and age matched control retinas were examined from hatch up to 730 days of age. Thickness of retinal layers at six retinal regions was measured from plastic embedded sections....
Topics
- Animals
- Apoptosis
- Blindness
- Cell Count
- Chickens
- Disease Models, Animal
- Fluorescent Antibody Technique, Indirect
- Genes, Recessive
- Glial Fibrillary Acidic Protein
- Guanylate Cyclase