Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens.

Investigative ophthalmology & visual science - 1 Nov 2006

Tummala Hemanth, Ali Manir, Getty Paul, Hocking Paul M, Burt David W, Inglehearn Chris F, Lester Douglas H

Abstract excerpt

PURPOSE: To identify the gene defect that causes blindness and the predisposition to embryonic death in the retinopathy globe enlarged (rge) chicken. METHODS: Linkage analysis, with previously uncharacterized microsatellite markers from chicken chromosome 1, was performed on 138 progeny of an rge/+ and an rge/rge cross, and candidate genes were sequenced. RESULTS: The rge locus was refined and the gene for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blindness
Share to Chick Embryo

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Heterotrimeric GTP-Binding Proteins

Share to Hypertrophy

Share to Retinal Degeneration

Share to Transducin

Source

Identifiers

PMID: 17065478
DOI: 10.1167/iovs.06-0292

Genes

GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens.PMID 17065478Read ↗

Recessive Retinopathy Consequent on Mutant G-Protein β Subunit 3 (GNB3).Semantic proximity Read ↗

Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism.Semantic proximity Read ↗

Severe retinal degeneration caused by a novel rhodopsin mutation.Semantic proximity Read ↗

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel–associated retinopathySemantic proximity Read ↗

Detailed histopathologic characterization of the retinopathy, globe enlarged (rge) chick phenotype.Semantic proximity Read ↗

Genetic, ophthalmic, morphometric and histopathological analysis of the Retinopathy Globe Enlarged (rge) chicken.Semantic proximity Read ↗

Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration.Semantic proximity Read ↗

Insights into the role of RD3 in guanylate cyclase trafficking, photoreceptor degeneration, and Leber congenital amaurosisSemantic proximity Read ↗

Gene expression patterns of chicken neuregulin 3 in association with copy number variation and frameshift deletion.Semantic proximity Read ↗

Mutations in the CNGB3 gene encoding the beta-subunit of the cone photoreceptor cGMP-gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21.Semantic proximity Read ↗

Analysis of the rdd locus in chicken: a model for human retinitis pigmentosa.Semantic proximity Read ↗

Mammalian homolog of Drosophila retinal degeneration B rescues the mutant fly phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.