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Müller Glia Activation in Response to Inherited Retinal Degeneration Is Highly Varied and Disease-Specific

20 Mar 2015

Abstract excerpt

Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells. It is typically assumed that photoreceptor loss leads to an upregulation of glial fibrilliary acidic protein (Gfap) and other intermediate filament proteins, together with other gliosis-related...

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PMID: 25793273
DOI: 10.1371/journal.pone.0120415

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